The mammalian chromosome is longitudinally heterogeneous in structure and function and this is the basis for the specific banding patterns produced by various chromosome staining techniques. The two most frequently used techniques are G, or Giemsa banding and R, or reverse banding. Each type of stained band is characterised by variations in gene density, time of replication, base composition, density of repeat sequences, and chromatin packaging. It is increasingly apparent that R and G bands, which are complementary to each other, (...) represent separate compartments of the euchromatic human genome, with R bands containing the vast majority of genes. R bands are also more GC‐rich, contain a higher density of Alu repeats, and replicate earlier in S phase, than G bands. These properties may be interdependent and may have coevolved. (shrink)

Heterochromatin remains condensed throughout the cell cycle, is generally transcriptionally inert and is built and maintainedbygroupsoffactors witheachgroupmember sharing a similar function. In mammals, these groups include sequence-specific transcriptional repressors, functionalRNAandproteinsinvolvedinDNAandhistone methylation. Heterochromatin is cemented together via interactions within and between each protein group and ismaintainedbythecell’sreplicationmachinery.Itcanbe constitutive (permanent) or facultative (developmentally regulated) and be any size, from a gene promotor to a whole genome. By studying the formation of facultative heterochromatin, we have gained information about how heterochromatin is assembled. We have (...) discovered that there are many different architectural plans for the building of heterochromatin, leading to a seemingly never-ending variety of heterochromatic loci, with each built according to a general rule. (shrink)

In order to understand ongoing activity, observers segment it into meaningful temporal parts. Segmentation can be based on bottom‐up processing of distinctive sensory characteristics, such as movement features. Segmentation may also be affected by top‐down effects of knowledge structures, including information about actors' intentions. Three experiments investigated the role of movement features and intentions in perceptual event segmentation, using simple animations. In all conditions, movement features significantly predicted where participants segmented. This relationship was stronger when participants identified larger units than (...) when they identified smaller units, and stronger when the animations were generated randomly than when they were generated by goal‐directed human activity. This pattern suggests that bottom‐up processing played an important role in segmentation of these stimuli, but that this was modulated by top‐down influence of knowledge structures. To describe accurately how observers perceive ongoing activity, one must account for the effects of distinctive sensory characteristics, the effects of knowledge structures, and their interactions. (shrink)

A simple tool is provided to assist researchers in assessing contributions to a scientific publication, for ease in evaluating which contributors qualify for authorship, and in what order the authors should be listed. The tool identifies four phases of activity leading to a publication—Conception and Design, Data Acquisition, Analysis and Interpretation, and Manuscript Preparation. By comparing a project participant’s contribution in a given phase to several specified thresholds, a score of up to five points can be assigned; the contributor’s scores (...) in all four phases are summed to yield a total “contribution score”, which is compared to a threshold to determine which contributors merit authorship. This tool may be useful in a variety of contexts in which a systematic approach to authorial credit is desired. (shrink)

This article defends what I call the atmospheric claim about trust: at least one form of trust manifests itself in human life in a manner that is like an atmosphere (generalized, ambient, and diffuse). I also provide a provisional defense of the claim that trust is a necessary condition for the thriving of something that matters to us. I offer a phenomenological sketch of existential trust. Existential trust is a primordial and atmospheric (generalized, ambient, and diffuse) manifestation of trust that (...) constitutes a fundamental way of being in relationship with the world as a whole such that one feels supportively upheld, vulnerably open, orientationally attuned, and demanded in relation to this world, with the overall effect of feeling at home in it. (shrink)

In this piece, the editor of Common Knowledge introduces a long-term project titled “Antipolitics: Symposium in Memory of György Konrád.” Konrád, who died in 2019, was a founding member of the Common Knowledge editorial board, and the symposium is meant to find present-day applications for the arguments of his book Antipolitics, published in 1982 in Hungarian. Although written under Cold War conditions and to that extent dated, the book is directed against politics and politicians as such: “What Machiavelli's Prince is (...) to would-be rulers, Antipolitics should be for those resistant to being ruled — a treasury of axioms and apothegms,” which this editorial collects, updates, and analyzes. Given that democratic systems and constitutions are “open and subject to further development,” Konrád urges us to devise and run experiments in governance that apply “creative imagination” to problems that, in better times, we might leave to politicians to resolve. “The crisis for democracy today,” Perl argues, “is that bad government (as Konrád, Václav Havel, and Adam Michnik defined it in the 1980s) appears to be what various electorates crave and therefore choose.” Realizing that elections produce, as Aristotle said, oligarchy rather than democracy, we should rethink majority rule and experiment with sortition as a counterpolitical means of self-government. (shrink)

In this introduction to Part 1 of “Contextualism—the Next Generation: Symposium on the Future of a Methodology,” the editor of Common Knowledge, a “journal of left-wing Kuhnian opinion,” reports that the new symposium responds to contextualist criticism of the previous CK symposium, which was on xenophilia. The content of the earlier symposium met with objections, from contextualists, on the grounds of methodology, and the new symposium questions the methodology of contextualism for the limits that it places on content as well (...) as on normative aims and degree of focus. Tracing the origins of contextualism to Kuhn and his theory that paradigms of scientific knowledge are incommensurable, this essay then argues that Kuhnian method is formal, with scant concern for content, and that Kuhn’s work was vatic, more than philosophical or historical. Kuhn’s depiction of his sudden, blinding realization that Aristotelian physics is correct in its own context is assessed as an ironic application of biblical scenes of revelation to what is, essentially, a process of scrupulous, piecemeal scholarship. What Kuhn unknowingly wanted, the essay concludes, was a combination of contextualism and phenomenology, as a means of knowing what it was like to believe in Aristotelian, as opposed to modern, concepts of matter, quality, space, void, position, change, and motion. The essay then introduces the first contribution to the new symposium: a monograph retrieving geometrical and taxonomic—Euclidean and Theophrastan—idioms of discourse about fictional characters and inquiring into their changing affective content. (shrink)

In this introduction to part 3 of the Common Knowledge symposium “Antipolitics,” the journal's editor argues that, apart from sortition, the best guarantees of safety in a democracy are, first, to augment judicial oversight of all political processes and, second, to exclude politicians from the process of selecting judges. “There can never be too much judicial interference,” he writes, “in what politicians regard as their domain.” The author reached this conclusion during attempts by the newly elected Israeli government, in the (...) spring of 2023, to make itself absolute by eliminating checks on its conduct that the Supreme Court had been developing and applying since the 1950s. Traditional Jewry and Judaism being notoriously hypernomian, the resistance to legality on the part of the ruling coalition has conveyed an aura of antinomian heresy. The choice in Israel appears to be between antipolitics and antinomianism, rather than between Left and Right politically—and the antipolitical model in Israel of a superintendent judiciary and an autonomous attorney general is arguably superior to the American prototype, even from the perspective (“all men are created equal..., endowed by their Creator with certain unalienable Rights”) that we have come to regard as quintessentially American. (shrink)

This essay, by the editor of Common Knowledge, responds to a piece by Dionigi Albera that, in turn, responds to Jeffrey Perl’s introduction, published in May 2017, to CK’s multipart symposium on xenophilia. Albera argues that the ambivalence that Perl observes in many instances of xenophilia needs genealogical explanation, and Albera turns for this purpose to analysis of the relationship between Aphrodite and Ares in Greco-Roman mythology. In the present piece, Perl extends that exploration in analysis of a series (...) of images in which the gods of love and war, along with their illegimate children Eros and Phobos, are given comical and often vulgar treatment by artists ranging from Botticelli and Mantegna, in the fifteenth century; to Titian, Veronese, and Tintoretto, in the sixteenth; to Rubens, Jan Bruegel the Elder, and Poussin, in the seventeenth; to Lagrenée, in the eighteenth; to David and Guillemot, in the nineteenth; to Jeff Koons in our own day. Perl and Albera agree with these artists that the antithetical pair, Aphrodite and Ares, have a fully logical, if furtive relationship in mythology, iconography, and psychology. The idealization to which the comic images respond—that when warriors make love, there is no warfare—is laughed, again and again, out of court. But Perl’s concern, unlike Albera’s, is that this cynicism on the part of artists and advanced intellectuals means that, despite their ostensible preference for peace over conflict, they will always find cause to undermine every effort to make way for peace. (shrink)

water paradox has long served as an argument against the Principle of Indifference. A solution to the paradox is proposed, with a view toward resolving general difficulties in applying the principle.

This essay introduces the second of three installments of an “elegiac symposium” in Common Knowledge on figures and concepts devalued in what Thomas Kuhn refers to as “paradigm shifts.” The essay suggests that Kuhn’s idea is provincial, in three specified senses, and then goes on to show how differently Japanese culture regards and manages major change. The author of this introduction, who is also the journal’s editor, begins by evaluating a triptych of 1895 by Toshikata as a response to the (...) seemingly revolutionary changes brought by the Meiji Restoration a generation before. He then goes on to discuss, as exemplary of Japanese attitudes toward change, the Shinto ritual during which the sacred shrines of Ise Jingū are torn down and rebuilt every twenty years. The essay concludes by explaining how the impetus for this ritual is also involved in less-exalted aspects of Japanese culture; for example, in the peculiarities of the market for ukiyo-e woodblock prints. Overall, this essay shows that Japanese ways of regarding concepts such as “old” and “new,” “continuity” and “change,” differ so radically from those presupposed in the West that the latter should be regarded as provincial rather than as universally valid. (shrink)

The Theory of Event Coding deals with brief events but has implications for longer, complex events, particularly goal-directed activities. Two of the theory's central claims are consistent with or assumed by theories of complex events. However, the claim that event codes arise from the rapid activation and integration of features presents challenges for scaling up to larger events.

Women are diagnosed with clinical depression at twice the rates as men. Treating depression through psychotherapy or medication both focus on changing an individual, rather than addressing socioecological influences or social roles. In the current study, participants read of systemic inequality contributing to differential rates of depression in either American men or women, or in two fictitious Australian First Nation groups. Participants then considered the acceptability and efficacy of treating depression through psychotherapy, medication, or social change. When socioecological inequities and (...) unequal social roles were presented through an unfamiliar foreign lens, participants were more likely to recognize the systemic unfairness, and endorsed social change more than psychotherapy or medication as a treatment strategy. However, when identical social inequities and social roles were presented through descriptions of American men and women, social intervention was less likely to be endorsed, and psychotherapy or medication gained in acceptability. Participants of color were also more likely to recognize and endorse social change as a strategy for treating depression, while those reporting a history of psychotropic medication for affective disorders rated medication as more effective and acceptable. (shrink)

People with disabilities suffer from pervasive inequalities in employment, education, transportation, housing, and health care compared to those who are not disabled. Moreover, people with disabilities are often subject to unjustified stigma and pity. In this paper, I will explain why these disadvantages violate relational egalitarian principles of justice. As I will show, my argument can account for both kinds of inequality that disabled people face.

This introduction to the third and final part of the Common Knowledge symposium “Unsocial Thought, Uncommon Lives” is reprinted here in a special issue of representative pieces from the journal’s first twenty-five years. The title is taken from an article by Isaiah Berlin in CK. Perl’s essay argues against the Aristotelian presumption that “man is a social animal” and explains that the CK symposium on unsocial thought was meant to substantiate that “societies do as a rule smother instinctive behaviors, but (...) in the process they also as a rule incarnate the least respectable instincts with greater force than individuals can do independently.... If even heroism and altruism, let alone standard social conduct, are oblique expressions of aggression, cruelty, and the will to power, then the obvious conclusion to reach is that human beings are not fit company for each other.... The standard means of veering off from this conclusion is to blame one’s own society, or aspects of contemporary society, and then to propose improvements. Historically, evidence suggests, efforts of this kind are opportunities for controversy and thus for exercise of the will to power. Social order is such that even the discussion of social order occasions conflict.” Perl goes on to argue that individualists and communitarians are “fundamentally in accord”: they are “teams” agreeing to the rules of a dubious conflict from which only “stylites, dendrites, and mendicants” have done what is required to exempt themselves. (shrink)

This paper concerns what if any obligations a “society of equals” has to criminal offenders after legal punishment ends. In the United States, when people leave prisons, they are confronted with a wide range of federal, state, and local laws that burden their ability to secure welfare benefits, public housing, employment opportunities, and student loans. Since the 1980s, these legal consequences of criminal convictions have steadily increased in their number, severity, and scope. The central question I want to ask is (...) whether the infliction of these burdensome legal consequences for those who have already been punished by the state is consistent with the ideal of equality. I argue that these collateral legal consequences violate relational egalitarian principles of justice and are thus objectionable. I conclude by examining possible objections to my argument. (shrink)

In his introduction to part 2 of the Common Knowledge symposium on xenophilia, the journal's editor tours the reader through two private apartments and through two public art collections in an effort to establish that aesthetically coherent mixtures of apparently immiscible objects from widely divergent cultures are possible and also morally glamorous. Xenophobia at its least reprehensible, he argues, is a fear of ecumenism and its consequences, as well as a fear of one's own conversion — of “turning Turk.” Xenophilia (...) at its most admirable is a pursuit of coherent mixtures where others cannot imagine their possibility. Bits lifted from reputedly pure and organic wholes may be transformed by means of overlap and mediated juxtaposition into a novel milieu that has a wholeness, authenticity, and charisma of its own. Such coherence depends on minds that are capable of loving what does not satisfy their narcissism and that can sense in the products of their own culture elements or signs of enervation, anomie, lack, derangement, waywardness, rigidity, preciousness, or warping. The author concludes that xenophilia neither signals nor facilitates the adulteration that xenophobes so fear. (shrink)

In this introduction to the first installment of the Common Knowledge symposium on xenophilia, the editor explains the rationale of the new project, citing increases in aggressive xenophobia internationally. He comments on the intergroup-relations theorist Todd Pittinsky's argument that, since tolerance is not logically the antithesis of negative feelings toward out-groups, even long-established traditions of toleration are inadequate to prevent intergroup aggression. Pittinsky proposes that tolerance be replaced, as a principle of peacekeeping, by the encouragement of positive feelings toward out-groups, (...) and the author of this essay responds by showing how the Freudian theory of ambivalence and the history of literature on which Freud drew in constructing it support Pittinsky's viewpoint. Enemies regularly fall in love, above all in Shakespearean drama, which Freud explains by arguing that all human relations are love-hate relations. Thus, this essay suggests, it takes as much psychic energy to repress the love in what appear to be relationships of hatred as to repress the hatred in what appear to be relationships of love. There is a metaphysical component as well to this argument: the xenophobe and xenophile equally presuppose that the identity principle is applicable to society as well as to mathematics; both assume that each discrete social group is self-identical and differs from all other groups more or less radically. The main difference between –phile and –phobe is the latter's relative incapacity to live with ambivalence. Given these arguments, one must expect to find negative as well as positive motives in the etiology and conduct of xenophilia—and the first installment of the Common Knowledge symposium is said to focus on cases of xenophilia in which varieties of enmity accompany that singular and underrated variety of love. (shrink)

Data gathered by investigators are used to test the validity of a specific scientific hypothesis. When the hypothesis relates to the biology of a disease or its treatment, then data sets may contain specific and identifiable medical information. Since the information in a clinical data set was gathered to test a specific hypothesis and there is usually a sponsor interested in the outcome, the issue of who owns the data is a critical one. In my opinion, data from both publicly (...) and privately funded research should be made available, in a format that protects confidentiality and intellectual property rights, to interested and responsible parties within a reasonable period of time after publication. (shrink)

In the last homily he gave before becoming Pope Benedict XVI, Cardinal Joseph Ratzinger described modern life as ruled by a “dictatorship of relativism which does not recognize anything as definitive and whose ultimate goal consists solely” of satisfying “the desires of one’s own ego.” An eminent scholar familiar with the centuries-old debates over relativism, Ratzinger chose to oversimplify or even caricature a philosophical approach of great sophistication and antiquity. His homily depicts the relativist as someone blown about “by every (...) wind of doctrine,” whereas the relativist sticks firmly to one argument—that human knowledge is not absolute. Gathering prominent intellectuals from disciplines most relevant to the controversy—ethics, theology, political theory, anthropology, psychology, cultural studies, epistemology, philosophy of science, and classics—this special double issue of _Common Knowledge_ contests Ratzinger’s denunciation of relativism. One essay relates the arguments of Ratzinger to those of two other German scholars—the conservative political theorist Ernst Wolfgang Böckenförde and the liberal philosopher and sociologist Jürgen Habermas—since all three men assume that social order depends on the existence of doctrinal authority. The contributors here argue for an intellectual and social life free of the desire for an “infantilizing” authority. One proposes that the Christian god is a relativist who prefers limitation and ambiguity; another, initially in agreement with Ratzinger about the danger relativism poses to faith and morals, then argues that this danger is what makes relativism valuable. The issue closes with the first English translation of an extract from a book on Catholic-Jewish relations by Cardinal Carlo Maria Martini, one of the Catholic Church’s most progressive figures. _Contributors_. David Bloor, Daniel Boyarin, Mary Baine Campbell, Lorraine Daston, Arnold I. Davidson, John Forrester, Kenneth J. Gergen, Simon Goldhill, Jeffrey F. Hamburger, Julia Kristeva, Carlo Maria Cardinal Martini, Christopher Norris, Joseph Cardinal Ratzinger, Richard Shusterman, Barbara Herrnstein Smith, Jeffrey Stout, Gianni Vattimo. (shrink)

This essay, which is the editor's introduction to part 1 of a multipart symposium on quietism, also constitutes his call for symposium papers. The symposium is meant be comprehensive. It is described as political and broadly cultural as well as religious, and in religious terms is said to cover not only the Catholic and Protestant quietisms (most properly so called) of the late seventeenth and eighteenth centuries, but also the proto-quietisms of the medieval Western church and reputedly quietist aspects of (...) the Gnostic, Eastern Orthodox, early Hasidic, Shi'ite, Jain and other Indic, Taoist, and Zen religious traditions. This introduction emphasizes the secular approaches, mostly antipolitical or postphilosophical, that wear the adjective “quietist” metaphorically, including the postmodern currents that Martha Nussbaum has named “hip quietism” and the “minimalist” philosophical version developed by Wittgenstein and some of his successors, notably Richard Rorty. This introduction concludes with attention to Rorty's late essay “Naturalism and Quietism,” then with a dedication of the entire symposium to Rorty's memory. (shrink)

In this introduction to part 2 of the Common Knowledge symposium “Peace by Other Means,” the journal's editor reflects on the difference between the contributions to parts 1 and 2. Whereas the first installment concentrated on ethnography, the second focuses on the peacemaking repertoire of the Greco-Latin tradition, whose basis is psychological. That tradition is characterized by its refusal of wishful thinking about human nature and, in particular, by its doubt about claims that human drives other than thumos — the (...) rage for self-aggrandizement — motivate the initiators of wars. Given this assumption about motive, the Greco-Latin tradition tends also to regard negotiations based on the rational discussion of material interests as unlikely to succeed. Success requires symbolic and ritual gestures — acts of self-humiliation on the part of those apparently with the greatest power — by which thumos is propitiated and pacified. Most of the introduction considers cases of such settlements, including two contemporary efforts at ritual peacemaking, a successful one by Queen Elizabeth II in Ireland and an unsuccessful one by Pope Francis in the Middle East. (shrink)

In this piece, the editor of Common Knowledge offers excerpts from his two-year correspondence with a reader in Hong Kong, who was drawn to arguments made in the journal about maintaining “quietism and resistance in the face of vile behavior.” In the summer and fall of 2019, during the insurrection in Hong Kong, his correspondent shifts rapidly from taking comfort in CK’s defense of quietism to a full embrace of “uncivil disobedience.” She implies that the solidarity the editor expresses with (...) Hong Kong is merely rhetorical, and he responds by writing this article and quoting in it the entire text of the 1984 Joint Declaration of the Chinese and British governments on the question of Hong Kong. The declaration’s guarantees of autonomy and civil rights appear in bold italics. The editor concludes by suggesting that it falls to the United Nations Security Council to enforce the terms of the treaty. (shrink)

In this brief introduction to part 2 of the Common Knowledge symposium “Whatever Happened to Richard Rorty?” the journal’s editor asks why Rorty was dependent on Thomas Kuhn, rather than Paul Feyerabend or the then-rising stars of “science studies” (such as Bruno Latour), for science-centered arguments to support his own philosophical neopragmatism. The editor cites a letter from Rorty sent to him in the early 1990s, suggesting that the differences between Feyerabend and himself were temperamental more than philosophical. Rorty enjoyed (...) referring to himself and others like him as “we atheists,” by which he seems to have meant “those of us repelled by extravagant or overheated claims and absolutes.” His tendency was thus to pull back in what might seem to be bored alarm from treatments of science as superior, perilous, or in any essential way different from other forms of intellectual discourse. Rorty’s understanding of these approaches to science as temperamentally religious appears lately to have been vindicated by the emergence of the primeval goddess “Gaia” in the rhetoric of science studies. (shrink)

A juvenile. Not unique, but a rarity for a university press. The publisher characterizes Skammy (about Skamandrios) as: an exciting story of adventure and mighty deeds, Skammy...struggles with great questions of life, death, and immortality. It offers models of human thought, behavior, and morality ranging from heroism, courage, integrity, and endurance to cowardice and treachery.".